PREMIER Biosoft announces the release of SimGlycan® Enterprise Edition 5.0 to support automated mass spectrometry glycan quantitation analysis using Thermo Scientific™ aminoxyTMT™ Reagents
Palo Alto, California – June 11, 2014: PREMIER Biosoft, a next generation leader in bioinformatics, today announced the release of Enterprise Edition of SimGlycan® v. 5.0, a comprehensive high throughput tool to provide support for glycan quantitation using Thermo Scientific™ aminoxyTMT™ for MS/MS glycan data analysis workflows. Additionally, it can be used for processing of LC-MS data for peak detection, peak picking and alignment of glycans based on retention time, precursor m/z values and observed intensities across multiple samples.
The Thermo Scientific™ aminoxyTMT™ reagents are designed to provide efficient relative quantitation of carbohydrates, improve labeled-glycan ionization efficiency and increase analytical throughput. These reagents can be used for quantitative analysis of native N-glycans by direct or LC-coupled ESI-MS. Using SimGlycan®, glycans are quantified by measuring reporter ion peak intensities from the corresponding MS/MS spectra. Various charts are provided to facilitate visualization of either the quantity of each glycan in different TMT channels or relative change in abundance of glycans across samples.
According to Julian Saba, Senior Scientist, life science mass spectrometry at Thermo Fisher Scientific, "One of the major new application areas of TMT reagents, until now being used for protein quantitation, is quantitative profiling of glycan isoforms and discovery of glycan biomarkers. PREMIER Biosoft's SimGlycan® is designed to ably provide the informatics support needed for analyzing the data generated by this workflow."
"The lack of informatics tools to automate the qualitative and quantitative analysis protocols till now remained a major challenge. The functionality now introduced in SimGlycan® is a major step towards narrowing the existing data analysis gaps. We are now offering the research community an effective tool for data validation, visualization and quantitation," said Arun Apte, CEO at PREMIER Biosoft.
For details, please visit: http://www.premierbiosoft.com/glycan/features/enterprise_edition.html
About PREMIER Biosoft
Founded in 1994, is a group of computer scientists and biologists dedicated to producing cutting edge intuitive software for research in life sciences. Our goal is to study the most recent innovations in life sciences and translate them into software products to aid research.
More information is available at: http://www.premierbiosoft.com