An Enterprise Edition of SimGlycan® is now available. If you are working with a private custom database or with proprietary data, the enterprise edition is the secure tool you are looking for to resolve novel glycans. You can add to or delete glycan structures from the database or create your own sub-database for narrowing down the search, right from the convenience of your workstation. Structural information for multiple glycans can be stored in a single file and added to the database, saving time.
|When you buy the Enterprise Edition, you get:|
|- SimGlycan® client supported on Windows.|
|- A Smart Updater for both, the client and the database.|
|- SimGlycan® database and a database search engine supported on a Windows server.|
|- A user manager and backup system.|
|- Setup for 3 users. For additional users, please inquire.|
|- Unlimited technical support.|
SimGlycan® accepts the experimental MS/MS and Multi Stage/Sequential mass spectrometry (MSn, n>2) data, matches them with its own database of theoretical fragments and generates a list of probable candidate structures. Each structure is scored to reflect how closely it matches your experimental data. Apart from the structural information, other biological information for the probable molecular structures such as the glycan class (N-Linked, O-Linked heparin, lipopolysaccharide etc.), reaction, pathway and enzyme are also made available for easy reference in case of structural elucidation of glycans while in the case of glycopeptide qualitative analysis, information such as Protein ID, Protein Name, Source, Classification, Class, peptide sequence, peptide mass etc. are made available for identified glycopeptides.
Protein Glycosylation, which is a key post-translational modification, is the result of addition of a glycan to a peptide sequence. Glycopeptides are known to exhibit multiple biological functions. In order to identify distinct functional properties for defined structural features, detailed information on the respective glycan moieties is essential. In order to understand all these phenomena, glycosylation analysis is an area of growing interest. Glycans have also been found to participate in many biological processes including embryonic development, inter and intracellular activities, coordination of immune functions, pathogens homing on their host tissues, cell division processes and protein regulations and interactions.