MALDIVision

Citations and Reviews

Title/Description
Author and Details
Year

Mass spectrometry imaging with high resolution in mass and space.

Andreas Römppr and Bernhard Spengler, Institute of Inorganic and Analytical Chemistry, Justus Liebig University
doi: 10.1007/s00418-013-1097-6, Histochem Cell Biol. Jun 2013; 139(6): 759–783.PMCID: PMC3656243
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656243/

2013

 

 

 

 

 

 

 

 

 

 

 

 

 

 




A Comprehensive Data Processing and Visualization Software for MALDI Imaging Mass Spectrometric Data

Matrix Assisted Laser Desorption Ionization Imaging Mass Spectrometry (MALDI IMS) is a promising new technology for visualizing the spatial distribution of analytes viz., proteins, peptides, lipids, drug candidate compounds and biomarkers present in a sampled tissue section. MALDI tissue imaging enables researchers to visualize multiple molecular distributions across the surface of a sample without the need for chemical labels or antibodies. MALDI IMS has been increasingly used for candidate biomarker discovery, drug metabolite profiling, lipid analysis and proteomics. MALDI tissue imaging contributes significantly towards disease diagnosis and is now being used to address a number of clinical questions in diseases such as cancer and organ development.

To apply MALDI Imaging technology for clinical purposes, it is essential to develop a computationally powerful data processing and visualization informatics tool which can aid in successful analysis of the large data files obtained during an experimental run.

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  • Support for Large MALDI IMS Data Files
  • Data Processing
  • Comprehensive Image Display
  • Normalized Image Display
  • Co-register and Overlay Image
  • Import Tissue Optical Image
  • Extract Ion Image
  • Define Region of Interest
  • View Histogram and Cumulative Probability Graph
  • Export Ion Intensity Maps
  • Project Management

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