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MLPA® Designer

Citations and Reviews

Author and Details
Improving Mutation Screening in Familial Hematuric Nephropathies through Next Generation Sequencing Morinière, V., Dahan, K., Hilbert, P., Lison, M., Lebbah, S., Topa, A., Bole-Feysot, Christine., Pruvost, Solenn., Nitschke, Patrick., Plaisier, Emmanuelle., Knebelmann, Bertrand., Macher, Marie-Alice., Noel, Laure-Hélène., Gubler, Marie-Claire., Antignac, Corinne., Heidet, Laurence. (2014)
J Am Soc Nephrol, 25(12), 2740–2751.

Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides

Sabbaghian, N., Srivastava, A., Hamel, N., Plourde, F., Gajtko-Metera, M., Niedziela, M., Foulkes, W.D. (2014). Eur J Hum Genet, 22(4), 564-7.


Gain of 1q is associated with inferior event-free and overall survival in patients with favorable histology Wilms tumor: A report from the Children's Oncology Group

Gratias, E. J., Jennings, L. J., Anderson, J. R., Dome, J. S., Grundy, P., & Perlman, E. J. (2013). Cancer, 119(21), 3887-3894.


A 5.8 kb deletion removing the entire MNX1 gene in a Norwegian family with Currarino syndrome

Holm, I., Monclair, T., Lundar, T., Stadheim, B., Prescott, T. E., & Eiklid, K. L. (2013). Gene, 518(2), 457-460.


Identification of recurrent type-2 NF1 microdeletions reveals a mitotic nonallelic homologous recombination hotspot underlying a human genomic disorder

Vogt, J., Mussotter, T., Bengesser, K., Claes, K., Högel, J., Chuzhanova, N., ... & Kehrer‐Sawatzki, H. (2012). Human mutation, 33(11), 1599-1609.


BeeDoctor, a Versatile MLPA-Based Diagnostic Tool for Screening Bee Viruses

De Smet, L., Ravoet, J., de Miranda, J. R., Wenseleers, T., Mueller, M. Y., Moritz, R. F., & De Graaf, D. C. (2012). PloS one, 7(10), e47953. http://www.plosone.org/article/info%3Adoi%2F10.


Two New Rapid SNP-Typing Methods for Classifying Mycobacterium tuberculosis Complex into the Main Phylogenetic Lineages

Stucki, D., Malla, B., Hostettler, S., Huna, T., Feldmann, J., Yeboah-Manu, D., ... & Gagneux, S. (2012). PLoS One, 7(7), e41253.


Four unrelated patients with lubs X-linked mental retardation syndrome and different Xq28 duplications

Bartsch, O., Gebauer, K., Lechno, S., Van Esch, H., Froyen, G., Bonin, M., ... & Haaf, T. (2010). American Journal of Medical Genetics Part A, 152(2), 305-312. http://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.33198/full

Note: MLPA Designer, the lite version of AlleleID, includes the MLPA module of AlleleID.

Designs Highly Specific Oligos for MLPA® Assays

MLPA® Designer automates the design of highly specific synthetic oligos for MLPA assays. MLPA® (Multiplex Ligation dependent Probe Amplification) is a simple, high throughput multiplex PCR technique introduced by MRC-Holland that allows detection of abnormal copy numbers of up to 50 different genomic DNA or RNA sequences. This easy to perform technique requires the use of a thermocycler and capillary electrophoresis equipment. MLPA® Designer strictly adheres to the guidelines laid by MRC-Holland for designing of MLPA® oligos.

Data & Database Management

You can organize data of multiple experiments by creating separate projects for each of them. This functionality helps you to maintain a local database for sequence information and search results. There is no limitation to the number of projects that you can create using the program.


  • Sequence Import
  • Supports Designing MLPA® Oligos for Multiple Exons
  • Addition of MagPlex-TAG™ for Bead-Coupled MLPA Assays
  • Accurately Calculates Tm Values
  • Displays Secondary Structures
  • Displays MLPA® Oligos Properties
  • Export Results
  • Enables Design Control


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