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Lipid Profiling of Secreted Lung Lipids by MSMSALL Shotgun Lipidomics

Analysis of Permethylated Sialylated N-glycans

November 18, 2021

Recent advances in the analytical field, mainly mass spectrometry, has fueled lipidomics research. Data independent acquisition (DIA) based MS analysis is now considered as a go-to approach for performing lipidomics analysis. Among the DIA-based approaches, the sequential precursor ion fragmentation, MSMSALL [...]

Tags: MS Based Lipid Profiling, Shotgun Lipidomics Software

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Meet Us @ ASMS 2021

PREMIER Biosoft at 69th ASMS Conference

October 27, 2021

We are excited to announce that we are participating in the 69th ASMS Conference on Mass Spectrometry and Allied Topics to be held between October 31 - November 04, 2021 at Pennsylvania Convention Center, Philadelphia, PA.[...]

Tags: 2021 ASMS Conference, 69th ASMS Conference, Lipidomics, Biotherapeutics, Mass Spectrometry Data Analysis

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High-throughput Profiling of Permethylated Bovine Fetuin N-glycans

Analysis of Permethylated Sialylated N-glycans

September 30, 2021

Bovine fetuin is often used as a model glycoprotein for glycosylation studies in bio-therapeutics. Previous studies reveal that the glycan elution profile in bovine fetuin consists of a series of neutral glycans first, followed by monosialylated, disialylated, trisialylated, tetrasialylated, and finally pentasialylated species [...]

Tags: Analysis of Sialylated N-glycans, Permethylated N-Glycans, Mass Spectrometric Analysis of bovine fetuin N-glycans

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Data Independent Acquisition Methods in Lipidomics

Data Independent Acquisition Methods in Lipidomics

August 31, 2021

Lipids, one of the key components of the biological processes, play a critical role in various biochemical and signalling pathways. Structural characterization of these lipids can provide insights about their importance in various bioprocesses. With recent advancements in hardware and software technologies, mass spectrometry (MS) has emerged as the frontline approach for both untargeted and targeted lipidomics studies [...]

Tags: DIA MS, Data-independent Acquisition, Lipid Identification

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Informatics Challenges in Biotherapeutic Glycan Characterization

Biotherapeutic Glycan Characterization Software

July 19, 2021

Glycoproteins are now of prime interest to the biopharmaceutical industry, and are being approved for extensive clinical exploration. The qualitative and quantitative existence of glycans in a protein is crucial because the glycosylation (one of the most common post translational modifications) is found to have significant impact on physicochemical properties and thermal stability of a protein molecule [...]

Tags: Bioinformatics Software Tool, Structural Characterization of Glycans, Software for Biotherapeutic Characterization, Biotherapeutic Glycan Characterization

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Characterization of Metabolic Syndrome Lipids Using Waters SONAR Method

Characterization of Metabolic Syndrome Lipids

June 22, 2021

Over the past decade, lipidomics has been the area of focus mainly for its use and application for metabolic syndrome diseases like obesity & diabetes. The mechanism behind the role of obesity in leading to type 2 diabetes is still unknown. Understanding the molecular factors can provide insights into the mechanism behind the metabolic syndrome diseases [...]

Tags: Data Independent Acquisition, DIA for Untargeted Lipidomics, Characterization of Metabolic Syndrome Lipids

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Orbitrap-based DRAG Analysis – A Multiplex Workflow for Quantitative Glycomics

Comparison of Neutral & Sialylated Glycans Using DRAG With SimGlycan

May 25, 2021

Sialylation is an important biological modification that is involved in many cellular processes. Sialylated N-glycans appear to have crucial roles in the immune system, pathogen recognition and cancer. For understanding the therapeutic importance of sialylation, a direct comparison between the neutral and sialylated N-glycans is required [...]

Tags: Dual Reaction for Analytical Glycomics Analysis (DRAG), Comparison of Neutral and Sialylated Glycans, Quantitative Glycomics

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Webinar: GlycanExplorer Software for High Throughput Biotherapeutic Glycan Characterization

Complimentary Webinar on Biotherapeutic Glycan Characterization

April 28, 2021

PREMIER Biosoft, a leading Mass Spectrometry software solution provider, presented GlycanExplorer™ software at the Virtual Software Workshop organized by Thermo Fisher Scientific on April 21, 2021. GlycanExplorer is a software for high throughput analysis of released biotherapeutic N-glycans using high-resolution glycan spectral databases as well as in-silico fragment databases [...]

Tags: Biotherapeutic Glycan Characterization, Glycan Characterization Software

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Untargeted Lipidomics: An Unbiased High Coverage Lipid Profiling Workflow

Untargeted Lipidomics

March 17, 2021

Mass spectrometry (MS) based lipidomics, the study of lipids present & quantitated within a given biological system, comprises many different approaches for lipid profiling. However, it becomes a daunting task to select an ideal approach that can be robust and provide a high lipid coverage [...]

Tags: Untargeted Lipidomics, Lipid Profiling and quantitation Workflow

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Metabolite Profiling of Stingless Honey Bee Samples using a MALDI-TOF MS Instrument

Untargeted Metabolite Profiling of Stingless Honey Bee Samples

February 25, 2021

Metabolomics, the last endpoint of the omics cascade, is the comprehensive study of metabolites present within a biological system. Analysis of metabolites provides insights into physiological, pathological, and biochemical changes during cellular regulation [...]

Tags: Untargeted Metabolomics Workflows, Honey Bee Metabolite Identification, Metabolite Profiling and Identification, Honeybee Profiling

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Spectral Matching Vs. in-silico Fragment Matching – Rendering Confidence to Bio-therapeutic Glycan Characterization

Meet Lipid Quantitation Challenges

January 13, 2021

Recent advances in the field of mass spectrometry has opened new dimensions in biopharmaceutical and biomedical analysis. Monoclonal antibodies (mAbs) are acting as a driving force in the growth of the biopharmaceutical industry [...]

Tags: Biopharmaceutical Glycan Characterization, Spectral Pattern Matching, Mass Spectral Library

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Targeted Lipidomics- Easing the Lipid Quantitation Challenges

Meet Lipid Quantitation Challenges

December 15, 2020

Quantitation of lipids is significant because lipids have a widespread biological role in the body in terms of intracellular signalling or local hormonal regulation etc. Due to their structural complexity, attaining absolute quantitation of lipids is not feasible experimentally using mass spectrometry [...]

Tags: Meet Lipid Quantitation Challenges, Targeted Lipidomics, SimLipid Software Solution

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Comparative Fucosylation Analysis in Cetuximab and Human IgG N-glycans

Cetuximab & Human IgG N-glycans Analysis

October 20, 2020

Glycosylated biotherapeutics comprise nearly more than half of all the biotherapeutics. Among these, glycosylated biotherapeutics, monoclonal antibodies (mAbs) hold the majority and constitute approximately half of the biopharmaceutical market. The success of a therapeutic antibody solely depends upon its clinical efficacy. Maximized efficacy reduces the required dose of a drug during a treatment, which eventually reduces the cost of the treatment [...]

Tags: N-Glycan Profiling of Cetuximab, N-Glycan Profiling of Human IgG, Fucosylation of Human IgG, Glycosylated Biotherapeutics

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Rapid Profiling of RapiFluor-MS Labeled NIST mAb N-glycans using UHPLC Coupled with an Orbitrap-based Mass Spectrometer

RapiFluor-MS Labeled NIST mAb N-glycans Profiling

September 08, 2020

In recent years, recombinant antibodies emerged as one of the front runners in the pharmaceutical industry. To perform quality control of these antibody drugs, a reference standard was needed. After rigorous analysis, the National Institute of Standards and Technology (NIST) has identified a protein for this purpose and labeled it as NIST monoclonal antibody [...]

Tags: Orbitrap MS N-glycan analysis, N-Glycan Profiling of NIST Antibody, Profiling of RapiFluor-MS N-Glycan

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High Throughput Shotgun Lipidomics Analysis Workflow for MALDI-MS Data using SimLipid® Software

High Throughput Shotgun Lipidomics Analysis

August 04, 2020

Lipidomics, an omics discipline, is a study about quantitative characterization of lipids generated by cells, tissues and organisms. Mass spectrometry (MS) plays a vital role in lipidomics enabling accurate identification of lipids of different classes and subclasses with high sensitivity [...]

Tags: Shotgun Lipidomics Analysis, MALDI-MS Data Analysis, Lipidomics Identification and Quantitation

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Complete Profiling of Procainamide Labeled Human IgG N-Glycans using UHPLC Coupled with an Orbitrap-based Mass Spectrometer

Profiling of human IgG N-Glycans

July 07, 2020

Immunoglobulin G (IgG) comprises almost three fourth of serum antibodies in humans. Checking of IgG levels is one of the most common clinical approaches to measure an individual's immunity for specific pathogens. Glycosylated IgGs are considered to have a profound impact on the role of therapeutic antibodies mainly during antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity [...]

Tags: Profiling of IgG N-Glycans

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Macrolipidomic Profiling of Human Whole Blood using SimLipid Software for the Discovery of Novel Biomarkers of Omega-3 Polyunsaturated Fatty Acid Intake

Profiling of Lipid Species with SimLipid Software

June 11, 2020

The role of Omega-3 polyunsaturated fatty acid (PUFA) in diet and blood levels has been extensively researched. The most common approach involved is the use of gas chromatography coupled with flame ionization (GC-FID) detection to study either the total lipids in overall fatty acid metabolism or lipid fractions of plasma/serum. The results from GC-FID analysis target the conversion of fatty acyl chains on complex lipids into fatty acid methyl esters [...]

Tags: Lipidomic Profiling of Lipid Species, Novel Biomarker Discovery

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Rapid and Accurate Identification of Cetuximab N-Glycans using UHPLC Coupled with Orbitrap-Based MS with SimGlycan Software

Identification of N-Glycans from Cetuximab (mAb) using LC/MS analysis with SimGlycan Software

May 06, 2020

Metabolic reprograming allows breast cancer cells to adapt to different metastatic sites using different pathways based on the tissue site. Understanding these metabolic adaptations is vital in the study of breast cancer metastasis. 4T1 murine breast cancer cells, a highly aggressive model, was chosen for this study because 4T1 cells can spread to lymph nodes, bones, lungs, liver and brain. Lipid adaptations were studied between liver-metastatic and parental 4T1 cells using supercritical fluid chromatography (SFC) coupled with high-resolution mass spectrometry [...]

Tags: N-Glycan Identification N-glycan Analysis using LC-MS/MS, Cetuximab Identification Coupled with Orbitrap-Based MS

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Fast Supercritical Fluid Chromatography (SFC) Separation and Shotgun Lipidomics with High Resolution Mass Spectrometry (HRMS) for the Study of Breast Cancer Metastasis

Study of Breast Cancer Metastasis using SFC MS and DIA FIA MS with SimLipid Software

March 02, 2020

Metabolic reprograming allows breast cancer cells to adapt to different metastatic sites using different pathways based on the tissue site. Understanding these metabolic adaptations is vital in the study of breast cancer metastasis. 4T1 murine breast cancer cells, a highly aggressive model, was chosen for this study because 4T1 cells can spread to lymph nodes, bones, lungs, liver and brain. Lipid adaptations were studied between liver-metastatic and parental 4T1 cells using supercritical fluid chromatography (SFC) coupled with high-resolution mass spectrometry [...]

Tags: Supercritical Fluid Chromatography, Breast Cancer Metastasis, Shotgun Lipidomics

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Back from APA India 2020!

PREMIER Biosoft at APA India Conference 2020

February 26, 2020

PREMIER Biosoft is back from Applied Pharmaceutical Analysis-India (APA) 2020 Conference organized by the Boston Society at Courtyard by Marriott, Ahmedabad, India from February 23-25, 2020. We showcased SimGlycan® software - A high throughput software solution for mass spectrometry based glycan and glycopeptide analyses. [...]

Tags: APA India 2020 Conference, APA INDIA 2020

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Meet Us @ Applied Pharmaceutical Analysis-India (APA) 2020 Conference

PREMIER Biosoft at APA India 2020

February 11, 2020

We are excited to announce that we are participating in the Applied Pharmaceutical Analysis-India (APA) 2020 Conference organized by the Boston Society at Courtyard by Marriott, Ahmedabad, India from February 23-25, 2020. We are showcasing SimGlycan® software - A high throughput software solution for mass spectrometry based glycan and glycopeptide analyses [...]

Tags: Applied Pharmaceutical Analysis India, APA India 2020 Conference

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Identification and Quantitation of 2-AA derivatized N-Glycans from Infliximab using UHPLC coupled to a Thermo Scientific™ Q Exactive™ Plus mass spectrometer with SimGlycan software

SimGlycan Software for Glycans Identification & Quantitation

January 28, 2020

Triacylglycerols (TAG) constitute a majority of plant-based oils, which are the primary source for dietary fat. High structural diversity poses a major challenge for the analysis of these TAGs. There are limited literary reports for other lipid species like diacylglycerols (DAG), phospholipids and sterols from these oils [...]

Tags: Glycans Identification & Quantitation, 2-AA Glycan Identification

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Untargeted Macrolipidomic Workflow for Plant Based Oils using Waters Synapt G2Si QTOF Instrument and SimLipid Software

Analysis of TAG lipids using  Waters Synapt G2Si QTOF

December 18, 2019

Triacylglycerols (TAG) constitute a majority of plant-based oils, which are the primary source for dietary fat. High structural diversity poses a major challenge for the analysis of these TAGs. There are limited literary reports for other lipid species like diacylglycerols (DAG), phospholipids and sterols from these oils [...]

Tags: Untargeted Macrolipidomic Profiling, Plant-Based Oils, Triacylglycerol (TAG) Plant-Based Oils

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Lipidomics Workflow using Nanoflow Separation Coupled with TIMS and PASEF

Lipid Identification & Quantitation method

October 16, 2019

Liquid chromatography (LC) coupled with mass spectrometry (MS) is an established method for lipidomics workflow. Sensitivity and high starting amounts are the major limitations of this method. To overcome these limitations, a novel approach utilizing nanoflow separation and trapped ion mobility spectrometry (TIMS) was implemented to increase sensitivity. Also, TIMS was synchronized with precursor selection based on parallel accumulation serial fragmentation (PASEF) showed a ten-fold increase in MS/MS acquisition rates [...]

Tags: Lipidomics Workflow, Lipid Identification & Quantitation Method, Trapped Ion Mobility Spectrometry (TIMS)

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A High Throughput Qualitative and Quantitative Lipidomics Workflow using FIA-HRMS with Tandem MS (DIA) Based Method with SimLipid Software

LC-MS based Lipidomics workflow for profiling of lipids

September 09, 2019

Application of flow injection analysis (FIA) coupled with high-resolution mass spectrometry (HRMS) is currently trending as a suitable method for lipidomics study. In this method, FIA coupled with Thermo Orbitrap MS instrument assists in measuring data-independent acquisition (DIA) based MS/MS data for lipid species. MS and MS/MS data acquired were subjected to data processing, lipid identification, and quantitation using SimLipid [...]

Tags: Lipid Quantitation, Data Independent Acquisition, High Resolution Mass Spectrometry

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Lipidomics Analysis using LC-MS data from Thermo Orbitrap Velos Pro MS instrument with SimLipid Software

LC-MS based Lipidomics workflow for profiling of lipids

August 12, 2019

Recent advances in the fields of liquid chromatography (LC) and mass spectrometry (MS) has led to the development of novel lipidomics methods. We have developed a new LC-MS based lipidomics method for lipid profiling of Plasmodium berghei samples using UHPLC coupled with high resolution Orbitrap Velos Pro MS instrument [...]

Tags: Lipid Analysis, Lipidomics, Lipid Quantitation

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Thank You for Meeting Us @ ASMS 2019

PREMIER Biosoft @ ASMS 2019

June 11, 2019

PREMIER Biosoft is back from 67th ASMS Conference on Mass Spectrometry and Allied Topics, Atlanta, GA, USA. This year, we showcased SimLipid®- a high throughput lipid characterization software and SimGlycan®- a high throughput glycan identification software tools. We would like to extend our sincere gratitude to researchers from our academic collaborators [...]

Tags: ASMS 2019, 67th ASMS Conference on Mass Spectrometry and Allied Topics

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Meet Us @ ASMS 2019

PREMIER Biosoft @ ASMS 2019

May 17, 2019

We are excited to announce that we are participating in the 67th ASMS Conference on Mass Spectrometry and Allied Topics at Georgia World Congress Center (GWCC) from June 2 – 6, 2019, Atlanta, GA USA.

We are showcasing

  • SimLipid® - Our high throughput lipid characterization software, and
  • SimGlycan® - A high throughput glycan & glycopeptide identification software [...]

Tags: ASMS 2019, 67th ASMS Conference

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Thank you for joining us @APA INDIA 2019

Applied Pharmaceutical Analysis 2019

February 28, 2019

PREMIER Biosoft is back from the Applied Pharmaceutical Analysis-India (APA) 2019 Conference organized by the Boston Society at the Novotel Goa Resort and Spa, India from February 24-26, 2019. We showcased SimGlycan® software – one stop software solution for high throughput qualitative, and quantitative analysis of glycans in complex biological samples using mass spectrometry data [...]

Tags: APA INDIA 2019, Biopharma

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Meet Us @ Applied Pharmaceutical Analysis-India (APA) 2019 Conference

APA India 2019

February 13, 2019

We are pleased to announce that PREMIER Biosoft is participating in the Applied Pharmaceutical Analysis-India (APA) 2019 Conference organized by the Boston Society at the Novotel Goa Resort and Spa, India from February 24-26, 2019. This year’s theme is: Recent Advances and Innovations in Drug Development and Delivery for Therapeutic Small Molecules and Biologics [...]

Tags: APA 2019, Applied Pharmaceutical Analysis 2019

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Back from SFG 2018!

PREMIER Biosoft at SFG 2018

November 13, 2018

PREMIER Biosoft is back from the Society for Glycobiology 2018 Annual Meeting held in New Orleans, Lousiana, USA. We showcased SimGlycan® software– our high throughput glycan and glycopeptide identification software which uses mass spectrometry data.

Our CSO Dr. Sanjib N. Meitei delivered a talk entitled "SimGlycan: Speeding up LC-MS data processing - molecular feature finding, precursor peak picking, and MS/MS spectra annotation - of multiplexed glycomics experiments using Orbitrap-based mass spectrometers" [...]

Tags: Society for Glycobiology (SFG) Annual Meeting 2018, SFG Conference 2018

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Enabling Mass Spectrometry Based Targeted Glycomics Analysis

N-Linked Glycan Analysis

October 29, 2018

The analysis of N-linked glycans have become increasingly important in therapeutic protein drug development because of their altered bioactivity and efficacy triggered by glycosylation. The analysis protocol involves chromatographic separation of glycans prior to subjecting the sample to mass spectrometry. This reduces sample complexity, minimizes ion suppression, and increases dynamic range and separation of structural isomers. However, accurate identification of glycans in a high throughput manner is hampered by lack of glycan templates [...]

Tags: Mass Spectrometry Based N-Linked Glycan Analysis

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Informatics Support For MS Based Lipidomics Methods

Webinar on Lipidomics

October 25, 2018

PREMIER Biosoft hosted a complimentary webinar on “Informatics Support for MS Based Lipidomics Methods” and received an overwhelming response. A large number of attendees attended the live webinar. The webinar was presented by Dr. Sanjib N. Meitei Chief Scientific Officer, PREMIER Biosoft. We received several interesting questions from the attendees and it was a great experience interacting with them [...]

Tags: Informatics for Lipidomics Methods, Lipid Analysis Webinar

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Attend Our Talk @SFG 2018 Annual Meeting, New Orleans, Louisiana

PREMIER Biosoft at SFG 2018

October 22, 2018

We are pleased to announce that PREMIER Biosoft is participating at the SFG 2018 Annual Meeting at New Orleans Louisiana, USA from November 5-8, 2018.

We are showcasing SimGlycan® software– A high throughput software solutiuon for mass spectrometry based glycan and glycopeptide analyses. The latest version of the software includes a new improved peak picking algorithm, identification of isotope clusters and a faster database search [...]

Tags: SFG 2018 Annual Meeting, 2018 Society for Glycobiology Annual Meeting

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Live Webinar: Informatics Support For Mass Spectrometry Based Lipidomics Methods

Webinar On Lipid Analysis

October 11, 2018

PREMIER Biosoft is pleased to host a complimentary live webinar titled “Informatics Support For MS Based Lipidomics Methods” on October 24th, 2018, at 2:00 PM EST. The webinar will be presented by Sanjib N. Meitei, Ph.D., Chief Scientific Officer, PREMIER Biosoft.

Recent advancement in the field of Mass spectrometry (MS) has fueled lipidomics research. Many MS-based lipidomics methods – direct infusion, LC-, MALDI-, and LC-IMS-MS with tandem MS acquired in either DDA or DIA approach - were developed [...]

Tags: Lipidomics Webinar, Informatics For Lipid Analysis Webinar

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Automating Quantitation of Glycans with Stable Isotope Labels using Mass Spectrometry

Glycan Identification and Quantitation with Stable Isotope Labels

September 28, 2018

Recent trends in glycomics research show rapid growth of innovation related to accurate mass spectrometry based quantitative analysis of glycans. Stable isotope labels facilitate accurate identification and subsequent quantification of glycans using LC-MS or ESI-MS workflows. There are two major types of stable isotope labeling approaches reported in literature namely, (1) mass shift e.g., isotopic labeling using 18O/16O-Water or 12[C6]-2-AA)/13[C6]-2-AA, and (2) isobaric tags e.g., aminoxyTMT6, and QUANTITY [...]

Tags: Glycan Identification and Quantitation, Quantitation with Stable Isotope Labels

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Facilitating Identification of Glycerophospholipids and Glycerolipids with Details of the Fatty Acyl Composition using MS/MS Data

Identification of glycerophospholipids and glycerolipids

August 29, 2018

Over the decades mass spectrometry (MS) has evolved as the mainstay technology for characterization of complex bio-molecules such as proteins, peptides, glycans, lipids, and small molecule metabolites. MS-based workflows can overcome challenges to characterize complex molecules such as lipids.

Tandem mass spectrometry provides detailed information about lipid structures that facilitate identification of lipids not only based on their class specific headgroups but also on their fatty acyl composition [...]

Tags: Identification of Glycerophospholipids and Glycerolipids, MS/MS Data Analysis

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Enabling Large-Scale Mass Spectrometry Based Lipidomics Analysis

Mass Spectrometry Based Lipidomics Analysis Software

July 27, 2018

Rapid advancement in the field of analytical technology, particularly mass spectrometry (MS), is fueling lipidomics research. Novel applications of MS-based lipidomics - shotgun lipidomics, chromatography-based lipidomics, and LC-based lipidomics - for biological and biomedical research have been reported in published literature. Recently, Sadowski et al (2017) conducted a shotgun MS based large-scale lipidomic survey of 268 human stratum corneum (SC) samples to investigate the relationship between sampling depth and lipid composition from 14 different sampling sites on the human body [...]

Tags: Mass Spectrometry Based Lipidomics, Large-Scale Lipidomics Analysis Software

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Back from Metabolomics 2018!

PREMIER Biosoft at Metabolomics 2018

July 03, 2018

PREMIER Biosoft is back from 14th Annual Conference of the Metabolomics Society, Seattle Washington. It was great seeing you all there!

We showcased SimLipid® – a high throughput lipid characterization software, and SimMet® – A high throughput metabolite analysis software [...]

Tags: 14th International Conference of the Metabolomics Society, 2018 Metabolomics Conference

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Bioinformatics for Lipidomics: Keeping Up with The New MS Based Lipidomics Workflows with MS/MS Data Acquired using Various DIA Techniques

DIA for Shotgun lipidomics workflow

June 26, 2018

The rapid advancement in mass spectrometry (MS) technology led to the development of new lipidomics workflows. Recently, vendors manufacturing mass spectrometers have introduced various MS-based lipidomics workflows with MS/MS acquired using data-independent acquisition (DIA) approaches. The DIA-MS/MS methodology has been enabled on (Q)TOF - Waters Corporation, MSE, Agilent Technologies, All Ions MS/MS, SCIEX, Infusion MS/MSALL and Orbital ion trap - Thermo Fisher Scientific; All Ion Fragmentation-instruments [...]

Tags: Data Independent Acquisition, Ion Mobility Mass Spectrometry

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Meet Us @ Metabolomics 2018 Seattle, Washington

Meet PREMIER Biosoft at ASMS 2018, San Diego CA, June 3-7, 2018

June 15, 2018

We are pleased to announce that PREMIER Biosoft is participating in the 14th Annual Conference of the Metabolomics Society, Washington State Convention Center, from June 24-28, 2018 in Seattle, Washington.

We are showcasing SimLipid® – our high throughput lipid characterization and quantitation software, and SimMet® – A high throughput metabolite analysis software [...]

Tags: 2018 Metabolomics Conference, Metabolomics 2018

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Thank You for Joining Us @ASMS 2018!

Meet PREMIER Biosoft at ASMS 2018, San Diego CA, June 3-7, 2018

June 08, 2018

PREMIER Biosoft is back from 66th ASMS Conference on Mass Spectrometry and Allied Topics, San Diego CA, USA. It was wonderful seeing you all there! We showcased our software tools, namely, SimLipid® – a high throughput lipid characterization software, and SimGlycan® – a high throughput glycan & glycopeptide identification software. During the five-day event, we participated in multiple events organized in collaboration with our partner companies. Here are the highlights [...]

Tags: 66th ASMS Conference on Mass Spectrometry and Allied Topics 2018

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Meet Us @ ASMS 2018

Meet PREMIER Biosoft at ASMS 2018, San Diego CA, June 3-7, 2018

May 14, 2018

We are excited to announce that we are participating in the 66th ASMS Conference on Mass Spectrometry and Allied Topics at San Diego Convention Center from June 3 – 7, 2018, San Diego CA USA.

We are showcasing SimLipid® - Our high throughput lipid characterization software, and SimGlycan® - A high throughput glycan & glycopeptide identification software.

We are participating in multiple events organized by our partner companies. The events are as follows [...]

Tags: 66th ASMS Conference on Mass Spectrometry and Allied Topics 2018

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Bioinformatics Tool for Mass Spectrometry Based Lipidomics Workflows

Bioinformatics Tool for Mass Spectrometry Based Lipidomics Workflows

April 26, 2018

The main biological functions of lipids include energy storage, acting as structural components of cell membranes, and participating as important signaling molecules. Lipids play diverse and important roles in nutrition and health e.g., abnormal levels of certain lipids, particularly cholesterol, and trans fatty acids are risk factors for heart disease and other diseases. Lipids also play a key role in cell, tissue and organ physiology with diseases such as cancer and diabetes which involve disruption of metabolic enzyme pathways [...]

View the list of MS based lipidomics workflows supported by SimLipid software.

Tags: MS Based Lipidomics Workflows, Lipidomics Software

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Automating Rapid and Accurate Identification of the N-Glycans of a Recombinant Human Erythropoietin (rhEPO) Expressed by a Chinese hamster Ovary (CHO) Cell Line using Tandem MS/MS Data

Typical native N-Linked Glycans of rhEPO expressed by CHO cell line (Szabo et al. Journal of proteome research. 2018 Feb 16.)

March 27, 2018

Biopharmaceuticals represent the fastest growing sector of the pharmaceutical industry, mainly driven by a rapid expansion in the manufacture of recombinant protein-based drugs [1]. The majority of the therapeutic proteins are glycoproteins (monoclonal antibodies, blood proteins, growth factors, vaccines, fusion proteins) and hence, glycosylation is the most prominent post-translational modifications occurring on these protein drugs.
List of N-Glycans of CHO Cell Lines [...]

Tags: Identification of N-glycans of rhEPO Expressed by CHO Cell Line, Glycan Identification using LC-MS Methods with SimGlycan Software

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Back from APA 2018

PREMIER Biosoft at APA India 2018 Conference

March 01, 2018

PREMIER Biosoft is back from the Applied Pharmaceutical Analysis-India (APA) 2018 Conference held at The Westin, Pune, Koregaon Park, India from February 26-27, 2018. We showcased SimGlycan® software – a novel software solution for facilitating high throughput qualitative, and quantitative analysis of glycans in complex biological samples using mass spectrometry data [...]

Tags: APA India 2018, APA India 2018 Conference

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PREMIER Biosoft @ Applied Pharmaceutical Analysis-India (APA) 2018 Conference at Pune, India

APA India 2018

February 19, 2018

We are pleased to announce that PREMIER Biosoft is participating in the Applied Pharmaceutical Analysis-India (APA) 2018 Conference at The Westin, Pune, Koregaon Park, India from February 26-27, 2018.

Our Chief Scientific Officer, Dr. Sanjib N. Meitei, will be presenting a poster titled, "Automated Identification and Quantitation of Stable Isotope Labeled Released N-Glycans by LC-MS with SimGlycan software" at the conference organized by the Boston Society [...]

Tags: APA India 2018, N-Glycan Quantitation

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Automated and Rapid Characterization of Low-Molecular-Weight Heparin Oligosaccharides using SimGlycan software v. 5.90

LC-MS/MS Data Analysis for Low-Molecular-Weight Heparin Identification

February 15, 2018

Unfractionated Heparin (UH) is an anticoagulant formulated of anionic, sulfated glycosaminoglycan. However, during infusion, this naturally occurring anticoagulant has been associated with various health problems. In contrast, low molecular weight heparins (LMWH) such as Enoxaparin, Parnaparin, Certoparin, Deltaparin, etc., are relatively efficient and safer. Therefore, an increasing demand to study these LMWH as new regulatory drugs has been on the rise [...]

Tags: Identification of Low-Molecular Weight Heparin, SCIEX TripleTOF 5600 Mass Spectrometer, Unfractionated Heparin, LC-MS/MS Glycomic Data Analysis

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LC-MS Based Glycomics Analysis using Orbitrap-based Mass Spectrometers with SimGlycan Software

LC-MS Glycomics Analysis by SimGlycan

November 28, 2017

The separation of glycans by chromatography prior to MS analysis can reduce sample complexity, minimize ion suppression and increase dynamic range and separation of structural isomers. Rapid development in mixed-mode columns and faster scanning in high resolution mass spectrometers has increased the number of glycans resolved and identified by LC-MS. However, these advancements have not only lead to large data sets, but have also resulted in complex datasets [...]

Tags: LC-MS Glycomics Analysis, Glycan Workflow Solutions, MS/MS Data Analysis, Thermo Scientific™ Orbitrap Fusion™ Tribrid™ mass spectrometer

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Thank You for Joining Us @SFG 2017!

Thank you for joining us @SFG 2017!

November 13, 2017

PREMIER Biosoft is back from the Society for Glycobiology 2017 Annual Meeting held at Portland Oregon, USA. We showcased SimGlycan® software– our high throughput glycan and glycopeptide identification software which uses mass spectrometry data. A live demo of SimGlycan software was organized demonstrating the qualitative and quantitative glycomic data analysis workflows [...]

Tags: SFG 2017 Annual Meeting, Society For Glycobiology Meeting, SFG Portland, Oregon

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Hear Our Talk @SFG 2017 Annual Meeting Portland, Oregon

Talk @ SFG 2017 Annual Meeting Portland, Oregon

October 31, 2017

We are pleased to announce that PREMIER Biosoft is participating in the SFG 2017 Annual Meeting at Portland Oregon, USA from November 5-8, 2017.

We will be showcasing SimGlycan® software– our high throughput glycan and glycopeptide identification software which uses mass spectrometry data. We have recently released SimGlycan v. 5.80, which now offers improved and more accurate assignment of precursor m/z values of MS/MS scans by identifying isotope clusters from MS1 data [...]

Tags: SFG 2017 Annual Meeting, Glycomics Workflow Solutions, Biopharma, Glycan Analysis, Glycan Quantitation, Glycan Isotopic Labeling

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Shotgun Lipidomics of Prostate Cancer Cells using Shimadzu LC/MS 8050 Triple Quadrupole Mass Spectrometer and Simplified Data Analysis by SimLipid® Software

Shotgun Lipidomics of prostate cancer cells

September 20, 2017

Lipidomics is an emerging field in biomedical research as lipids play an important role in cell, tissue and organ physiology and have potential as biomarkers of disease or treatment success. Lipidomics has also been widely studied in many areas including prostate cancer research, e.g., identification of lipid species in bio-fluids as biomarkers in diagnosis of prostate cancer with high sensitivity [...]

Tags: Shotgun Lipidomics, Lipidomics Analysis Software, Lipid Quantitation, Shimadzu LC/MS 8050 triple quadrupole mass spectrometer, Precursor Ion/Neutral Loss scanning (PIS/NLS) experiments, Prostrate cancer lipidomics analysis, High throughput lipidomic data analysis software

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An Integrated Workflow for Profiling and Semi-Quantitative Analysis of Lipids using Agilent 1260 Infinity SFC Coupled with a 6545 LC/QTOF High Resolution Mass Spectrometer with SimLipid® Software

Learn Profiling and Semi-Quantitative Analysis of Lipids using SimLipid Software

August 04, 2017

The lipidome covers a range of lipids from non-polar to polar. Profiling experiments often need two or more chromatography separation schemes to cover the range of polarities: a normal phase method and a reverse phase method. Quantitation of the annotated lipids requires investigation using a more targeted approach. We have described a comprehensive analytical method using supercritical fluid chromatography (SFC) coupled to high resolution mass spectrometry for the analysis of lipids covering the whole spectrum of lipid classes in a single run [...]

Tags: LC-MS Lipid Data Processing Software, Semi-Quantitative Analysis of Lipids, Quantitative Analysis of Lipids, Supercritical Fluid Chromatography Workflows, Agilent 6545 Q-TOF LC/MS System, SPLASH™ Lipidomix® Mass Spec Standard, LC-MS Lipidomics Analysis, MS/MS Data Independent Acquisition

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PREMIER Biosoft @ Metabolomics 2017 Brisbane, Australia

PREMIER Biosoft Participated in Metabolomics 2017 Brisbane, Australia

July 05, 2017

PREMIER Biosoft is back from the 13th Annual Conference of the Metabolomics Society, Brisbane, Australia. We showcased SimLipid® – a high throughput lipid identification, and quantitation software using LC-, MALDI-, Direct infusion-, MS, MS/MS, SONAR™, HDMSE, MSE, MPIS/NLS data.

We interacted with eminent scientists and many research laboratories which were looking for a software solution to automate their mass spectrometry lipidomic data analysis workflows. We provided live demo of SimLipid software, answered various questions on lipid MS data processing tool, and distributed free trial licenses [...]

Tags: Metabolomics 2017, Waters UPLC SONAR Data Analysis Software, Waters UPLC HDMSE Data Analysis Software, Lipid MS Data Processing Software, Shotgun Lipidomics Software, DIA Data Analysis, Lipidomics MS Data Analysis

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Meet Us @ Metabolomics 2017 Brisbane, Australia

Meet PREMIER Biosoft @ Metabolomics 2017 Brisbane, Australia June 25-29, 2017

June 19, 2017

We are pleased to announce that PREMIER Biosoft is participating in the 13th Annual Conference of the Metabolomics Society, Brisbane Convention & Exhibition Center, from June 25-29, 2017, Brisbane, Australia.

We will be showcasing SimLipid® – our high throughput lipid characterization software. We have just released SimLipid v. 6.00, the first ever software platform for automated lipidomic data analysis [...]

Tags: Metabolomics 2017, Waters UPLC SONAR Data Analysis Software, Waters UPLC HDMSE Data Analysis Software, Lipid MS Data Processing Software, Shotgun Lipidomics Software, DIA Data Analysis, Lipidomics MS Data Analysis

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PREMIER Biosoft @ 65th ASMS, Indianapolis, IN, USA

PREMIER Biosoft @ 65th Annual Conference on Mass Spectrometry and Applied Topics (ASMS)

June 14, 2017

PREMIER Biosoft is back from 65th Annual Conference on Mass Spectrometry and Applied Topics (ASMS), Indianapolis, IN, USA. It was a wonderful experience! We showcased our software tools, namely, SimGlycan® – a high throughput glycan & glycopeptide identification software, and SimLipid® – a high throughput lipid characterization software. During the four-day event, we participated in multiple events organized by our partner companies [...]

Tags: ASMS 2017, Waters UPLC-SONAR Data Analysis Software, Lipid MS Data Processing Software, Shotgun Lipidomics Software, DIA Data Analysis, Differential Analysis, Glycomics MS Data Analysis

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Meet Us @ ASMS 2017 Indianapolis, IN, June 4-8, 2017

Meet PREMIER Biosoft at ASMS 2017 Indianapolis, IN, June 4-8, 2017

May 25, 2017

We are pleased to announce that PREMIER Biosoft is participating in the 65th Annual Conference on Mass Spectrometry and Applied Topics (ASMS), Indiana Convention Center, from June 4-8, 2017, Indianapolis, IN, USA.

We are showcasing –SimGlycan® – our high throughput glycan & glycopeptide identification software and SimLipid® – our high throughput lipid characterization software [...]

Tags: ASMS 2017, Waters UPLC-SONAR Data Analysis Software, Lipid MS Data Processing Software, Shotgun Lipidomics Software, DIA Data Analysis, Differential Analysis, Glycomics MS Data Analysis

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Automating Untargeted and Targeted LC-MS Lipid Data Analysis with SimLipid® Software

Automating Untargeted and Targeted LC-MS Lipid Data Analysis with SimLipid

May 22, 2017

The presence of lipids in membranes, or as signaling molecules, is reflective of the physiological state of an organism at a given time. Comparative studies of the complex lipid mixtures found in cells and tissues could potentially reveal lipid biomarkers. It may be noted that a single analytical method to screen all lipids in a biological system has yet to be developed. Targeted and non-targeted approaches based on chromatography and mass spectrometry have been employed for such studies and they both involve the identification and measurement of lipids in the sample [...]

Tags: Lipidomics Software, LC-MS Lipidomics Analysis, Bruker’s UHR-QqTOF MS, Impact II™

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PREMIER Biosoft Wins Second Prize at APA – India 2017

PREMIER Biosoft Wins Second Prize at APA – India 2017

February 22, 2017

PREMIER Biosoft participated in Applied Pharmaceutical Analysis 2017 Conference (APA - India 2017), February 19-21, at Crowne Plaza Ahmedabad City Centre, India. Organized by the Boston Society, many leading scientists and experts participated in this conference to learn best practices in Bioanalysis, Biotransformation and Drug Discovery Strategies through a series of short courses, poster presentations, lectures, interactive sessions and panel discussions [...]

Tags: Structural Identification of Unknown Glycans, Low Molecular Weight Heparins (LMWH), High-throughput Glycan Search

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Automate Shotgun, LC-MS and MALDI-MS Based High-throughput Lipidomics using SimLipid®

Automate Shotgun, LC-MS and MALDI-MS based high-throughput lipidomics usin SimLipid®

February 10, 2017

A combination of different approaches namely ‘Shotgun lipidomics’, LC-MS, and MALDI-TOF is often necessary to detect the whole lipidome of an organism. Each lipid class has its own fragmentation patterns as well as ionization efficiency [1], thereby making the interpretation of MS/MS lipid spectra a challenging task. Currently available software tools lack the ability to analyze data generated by all the mentioned approaches in a single platform. We have developed SimLipid® software to address this challenge [...]

Tags: Shotgun Lipidomics, High-throughput Lipidomics, Lipid Structural Elucidation

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